They are all active devices, all playing together, all the time, on Windows 7 64 bit.
What are you using 11 com ports for?
K5TED's setup is not particularly unusual for a sophisticated hamradio setup.. I have 13 USB comports, 10 of which are in use and active all the time...... I could use all 13 at the same time if I wanted too. No problems, I have done it.
On my setup:
6 ports used for Navigator Digital Interface
1 for QS1R SDR
I for TS-590s ARCP control software
1 for Public Service Scanner control
1 for Cyberpower UPS monitoring software
3 others that are not used all the time.....
1 for Icom 7100 control software
1-Baofeng programming software
1- Blood Pressure Monitor Software
I use Win7/64.