I like to do what you are suggesting when driving
long distances also. (I.e. Los Angeles to Flagstaff).
In fact it's about the ONLY time I use VHF/UHF FM as
I am an HF guy but don't like big antennas on my car.
One thing I've found helpful is to carefully go over the route
BEFORE you leave, and program as many repeaters as possible along your route as possible and put them into memory. I just assign a memory number instead of entering the alphanumeric
city or location information. Then have a sheet on a clipboard
to consult. (I guess it would be easy to enter the city & town
names if you had the programming software, which I don't.)
The LAST thing you want to be doing when tired on the road,
or on the road period, is fiddling with odd splits, offsets, and
entering into memories while you are driving.
Now if you have a driving buddy who is a ham and knows
the radio, that's a different story.....assign looking for active
repeaters to HIM!