I recently started on 6M & 2M MS as well. So not expert but learning a lot here. My set-up: Moxon @ 22 ft for 6M, FT857 @ ~75W (throttled back for duty cycle), 6 el WA5VJB "cheapyagi" for 2M, 100W+ (TE systems amp with additional cooling). LMR-400 coax on both, and optional 6M preamp @ base of mast (seems to amplify local noise as much as signal so not using it much). I've made 6-12 (forget how many) total QSOs on 6 & 2 over several days preceeding Perseids and over the weekend (mostly Sat nigh & early Sun). Max distance just under 1,000 mi. All contacts using FSK-144 with WSJT 9.0-something (whatever is latest). Have PSK2K installed but no completed QSOs yet. Use the pinjockey site to look for someone at a reasonable distance who can walk you through 1st digital-MS QSO. Or find someone really close and go terrestrial to work out the bugs and learn the protocol. Helps if you already know you have a working PC-radio setup for any digital/soundcard modes - you can copy a lot of the settings into to WSJT software.
Digital MS is on/around 50.260 & 144.140 (FSK144), 50.230 (PSK2K, they are on a separate chat server, & forgot which freq for 2M!). Also terrestrial JT65A (JT65-HF software and the WSJT package) on 50.276 (lots of activity during the June-July E-skip season). Best operating time of day is morning around local sunrise +/- a few hours. WSJT software will show where to point antennas for best performance (usually slightly off the direct bearing because of the geometry of MS propagation) if you enter your 6-char grid and the other station's. QSOs can take most an an hour to complete using random (non-shower) meteors. (Hence the need for additional airflow to cool equipment running on a 30 sec full-on, 30 sec off cycle.) I've had some (not much) success trying to monitor the 6 & 2M calling frequencies and QSOs in progress per pinjockey - unless one (rarely, both) stations are in the right geometry with mine, I'm not going to hear anything.
In addition to the excellent materials on the W8WN qsl.net page, also check out the WSJT group site http://my.ykc.com/wa5ufh/default.htm
(somewhat more current) and read the WSJT software docs. Good luck, hope to work you!
73 Steve KS1G