Joe,
I did an install in my 2009 Honda Ridgeline (very similar platform) and have had no issues with RFI, etc. You can see some pics on QRZ. I ran the power cable through a grommet in the firewall direct to the battery, and removed a few trim panels where needed to route the cables & coax through to the rear of the cab to keep it clean. I did have to drill a small hole in the composite bed/liner to feed the cables outside, and used an aftermarket grommet to tidy it up when done.
Remote mounting definitely makes for a less bulky, nicer looking install, but I'm sure you could fit the 7300 in if you wanted to - where there's a will, and such...
Good luck with it, and show us some pics if you think of it once you're done!
Tony W3FLH