...When used to match impedance, the inherent loss of the tuner required to do so is far less than that on your coax making your concern trivial...
That may be a dangerous generalization, as those who have
had the coil melt in their tuner when using balanced line
can attest to.
Each case (and each band) needs to be considered individually.
If the SWR is relatively low (say, less than 5 : 1 at the
antenna) then coax may not be a bad choice. On the other
hand, with a long length of coax the losses may be high
enough that you never see an SWR over 5 : 1 even with the
far end of the cable open or shorted.
This is complicated by the fact that the losses for open wire
line published by ARRL for many years were too low - as if
they used the resistance of just one copper wire rather than
two in their calculations. And lines made of stranded
CopperWeld have higher losses, especially on the lower bands,
than any such calculations might suggest.
It also varies greatly with the type of tuner used, etc.
I measured more than a 3 dB difference among various
tuners when matching my doublet.
Fortunately we have tools that help us to calculate the
losses in such a system, including
AC6LA's TLDetails(runs on a PC), and Owen Duffy's
Transmission Line
Loss Calculator (runs in a browser window).
Using such tools will help to understand the possible
losses in an antenna configuration to see how suitable
it is for each situation.