The biggest danger regarding coupling between the two attic HF antennas is damage to a second HF receiver attached to the receiving antenna while the other is TXing. Avoid this pretty certain danger and you're free to experiment.
I've found that attic antennas are a major crapshoot. As careful as you are, sometimes you get lucky, sometimes you don't.
Last year I put an EFHW-4010-2K up in a high peaked attic with the 63 foot wire strung in an approximate V shape, apex due South, apex at the peak of the roof on the south side and wire ends down a bit lower at the feed/wire ends to the North. Dual common mode chokes were placed in series on the feedline just a few feet from the antenna, in contravention of usual practice for this resonant EFHW, where at least 7 feet separation between feedpoint and CMC is recommended. A third CMC is placed near the operating station three floors below, which only has a basic safety ground system. This contraption is fed with 75 feet of relatively lossy LMR-240 coax and is driven by a 500 Watt KPA-500, usually at no more than 350 Watts.
The roof is composite shingle and plastic air ducts, blown-in insulation and light fixtures with dimmers abound below the antenna, but there are no metallic linings on any of it. The HVAC unit is three floors below, though the touch controlled washer/dryer and smoke alarms are on the floor just below the attic.
To my VERY great surprise, this setup works better that the previous (and compromised) outdoor, lower height tree to tree configuration of the wire antenna. (when the trees both came down, so did the antenna). And there are NO detectable RFI/EMI issues. Go figure.
Even the RF safety survey results close (the high peaked rook helps a bit here).
Interestingly, the 49:1 antenna matching transformer does heat up a bit on 40M, as it always did - but LESS than it used to. The CMCs near the antenna actually get much warmer (never seen this before) which is why I use two to distribute the dissipation (yes, this actually works). So nothing gets hot enough to overheat, even in 140F summer attic temperatures. Most likely because this system is pretty lossy, I can also use the 10-15-20-40M wire antenna on 12, 17, 30 and 40M at reduced power - and make quite a few contacts.
THATS what I call LUCK.
I've made over 1,000 QSOs with it, out to just under 7,000 miles, with 2-3,000 mile QSOs being unremarkable. Modes worked have been digital (FT8) and SSB (yes, sideband DX). Seems to be pretty omnidirectional, according to PSKReporter RX mapping. The present very good propagation conditions definitely help. And so does the location right next to a large body of salt water.
But - I've seen others put in outside near-roofline and attic antennas that were nightmares and injected RFI/EMI into every circuit in the home, from the garage door opener to HVAC to lights and washer/dryer.
So experiment - and try improbable solutions. You may get lucky, too.
Brian - K6BRN