Thanks to each of you, Glen and Mike, for your suggestions. I had previously checked the com port and found that COM10, the one the software showed to use, said "in use by another program" even tho the radio's software was the only program that was in use. The message occurred no matter what other port I tried to use. I even reset them to show they were 'available' and things still didn't work. Trying the 'multiple button' combination didn't do anything for me either, Glenn, but I did find a video late last night about a computer programmed radio that was an HT. He showed the programming cord to his computer first then to the radio. So, I tried that this morning and the software did it's thing like there had never been a problem. I even powered off everything for a few minutes, left things connected, brought them back up and added more repeater frequencies to the list as a test. I hit SEND and it all worked as advertised. Maybe a gremlin got in there when I launched the program last week but it's working now the way I remember. So, Guys, thanks very much for helping... it's been a long few days!!
Jim